Shandong Provincial Key Laboratory of Metabolic Disease, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China.
J Anxiety Disord. 2013 May;27(4):435-7. doi: 10.1016/j.janxdis.2013.04.005. Epub 2013 Apr 30.
A functional variant in the mono-amine oxidase-A (MAO-A) gene has been shown to affect neural function related to several mental disorders. Therefore, we would like to ascertain if MAO-A could be a candidate gene for obsessive-compulsive disorder (OCD). We genotyped 414 healthy subjects and 240 OCD patients and found no significant difference not only in allele frequencies in male patients (χ(2) = 0.365, DF = 1, P = 0.545, odds ratio (OR) = 1.139, confidence interval (CI) = 0.75-1.74) but also in allele frequencies (χ(2) = 0.698, DF = 1, P = 0.404, OR = 0.849, CI = 0.579-1.246) or genotypic frequencies (χ(2)=0.933, DF = 2, P = 0.627) in female patients between OCD patients and controls. Given that this is the first investigation of this gene in OCD in a Chinese Han population, further studies are required to obtain more definitive conclusions in a larger number of subjects.
单胺氧化酶-A（MAO-A）基因中的一个功能性变体已被证明与几种精神障碍的神经功能有关。因此，我们想确定 MAO-A 是否可以成为强迫症（OCD）的候选基因。我们对 414 名健康受试者和 240 名 OCD 患者进行了基因分型，不仅在男性患者的等位基因频率（χ(2) = 0.365，DF = 1，P = 0.545，比值比（OR）= 1.139，置信区间（CI）= 0.75-1.74），而且在等位基因频率（χ(2) = 0.698，DF = 1，P = 0.404，OR = 0.849，CI = 0.579-1.246）或基因型频率（χ(2)=0.933，DF = 2，P = 0.627）方面，OCD 患者与对照组之间均无显著差异。鉴于这是首次在中国汉族人群中对该基因进行 OCD 研究，需要进一步的研究在更大数量的受试者中获得更明确的结论。
