Epidemiology and aetiology of neonatal seizures.

Neonatal seizures constitute the most frequent and distinctive neurological symptom in the neonatal period. Seizures in the neonatal period differ considerably from those observed later in life with respect to their aetiological profile and clinical presentation. In addition, the aetiological profile in preterm infants is different from that seen in term infants. Hypoxic-ischaemic encephalopathy is the most frequent cause of neonatal seizures in term babies followed by focal ischaemia (stroke), cerebral malformations and metabolic disturbances. In preterm neonates, intraventricular haemorrhage and infections cause most of the seizures reported in this group. Better neuroimaging techniques have reduced the number of undiagnosed cases, and the institution of newer neuroprotective strategies has influenced the outcome.