Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell Stem Cell. 2013 Jun 6;12(6):639-41. doi: 10.1016/j.stem.2013.05.020.
BMI1 is a known oncogenic transcriptional repressor in glioblastoma stem-like cells, but its downstream mediators are poorly understood. Recently, in Cancer Cell, Gargiulo et al. (2013) designed a rational in vivo RNAi screen based on BMI1 ChIP-seq from neural progenitors and identified functional tumor suppressor targets, including Atf3 and Cbx7.
BMI1 是神经胶质瘤干细胞中一种已知的致癌转录抑制因子，但它的下游介质知之甚少。最近，在 Cancer Cell 杂志上，Gargiulo 等人（2013 年）基于神经祖细胞中的 BMI1 ChIP-seq 设计了一个合理的体内 RNAi 筛选，并鉴定了包括 Atf3 和 Cbx7 在内的功能性肿瘤抑制靶点。
