• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

纯链黑菌素及分级链黑菌素复合物对弗瑞德病毒的活性

Activity of pure streptovaricins and fractionated streptovaricin complex against Friend virus.

作者信息

Horoszewicz J S, Rinehart K L, Leong S S, Carter W A

出版信息

Antimicrob Agents Chemother. 1975 Mar;7(3):281-4. doi: 10.1128/AAC.7.3.281.

DOI:10.1128/AAC.7.3.281
PMID:237470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429124/
Abstract

Chromatographic fractionation of streptovaricin complex yields two stable components enriched (4- to 16-fold) in activity directed against the polycythemic strain of Friend virus; both components apparently contain no streptovaricins. When compared with their unfractionated parent streptovaricin complex, eight individual intact streptovaricins (A through G and J) show at least a 30-fold reduction in antiviral activity. These results further support the conclusion that the diversified biological properties of streptovaricin complex probably reside in different molecular structures.

摘要

对链黑菌素复合物进行色谱分离可得到两种稳定成分,它们针对弗氏病毒红细胞增多症菌株的活性增强(4至16倍);这两种成分显然都不含链黑菌素。与未分离的亲本链黑菌素复合物相比,8种单独完整的链黑菌素(A至G和J)的抗病毒活性至少降低了30倍。这些结果进一步支持了以下结论:链黑菌素复合物的多种生物学特性可能存在于不同的分子结构中。

相似文献

1
Activity of pure streptovaricins and fractionated streptovaricin complex against Friend virus.纯链黑菌素及分级链黑菌素复合物对弗瑞德病毒的活性
Antimicrob Agents Chemother. 1975 Mar;7(3):281-4. doi: 10.1128/AAC.7.3.281.
2
Antivirion effects of streptovaricin complex against Friend virus.链黑菌素复合物对弗氏病毒的抗病毒体作用。
Antimicrob Agents Chemother. 1974 Nov;6(5):594-7. doi: 10.1128/AAC.6.5.594.
3
Differential susceptibility of spleen focus-forming virus and murine leukemia viruses to ansamycin antibiotics.脾灶形成病毒和鼠白血病病毒对茴香霉素类抗生素的敏感性差异
Antimicrob Agents Chemother. 1977 Jul;12(1):4-10. doi: 10.1128/AAC.12.1.4.
4
Effects of streptovaricins and their degradation products on RNA-directed DNA polymerase of Rauscher leukemia virus.链黑菌素及其降解产物对劳氏肉瘤病毒RNA指导的DNA聚合酶的影响。
J Natl Cancer Inst. 1977 Feb;58(2):239-43. doi: 10.1093/jnci/58.2.239.
5
Relative biological activities of individual streptovaricins and streptovaricin acetates.各链黑菌素及链黑菌素乙酸酯的相对生物活性。
Biochemistry. 1974 Feb 26;13(5):861-7. doi: 10.1021/bi00702a004.
6
Streptovaricins inhibit focus formation by MSV (MLV) complex.链黑菌素可抑制MSV(MLV)复合物的集落形成。
Nat New Biol. 1971 Aug;232(33):212-4. doi: 10.1038/newbio232212a0.
7
Streptovaricins inhibit RNA dependent DNA polymerase present in an oncogenic RNA virus.链黑菌素可抑制致癌RNA病毒中存在的RNA依赖性DNA聚合酶。
Nature. 1971 Mar 26;230(5291):249-50. doi: 10.1038/230249a0.
8
Inhibition by streptovaricins of Rauscher leukemia virus splenomegaly.链黑菌素对劳斯氏白血病病毒所致脾肿大的抑制作用。
Int J Cancer. 1974 Dec 15;14(6):817-25. doi: 10.1002/ijc.2910140616.
9
Effects of streptovaricins and their degradation products on infectivity of Rauscher leukemia virus.链黑菌素及其降解产物对劳氏肉瘤病毒感染性的影响。
J Natl Cancer Inst. 1977 Feb;58(2):245-9. doi: 10.1093/jnci/58.2.245.
10
Letter: Atropisomeric streptovaricins.信函:阻转异构链霉素
J Am Chem Soc. 1975 Jan 8;97(1):196-7. doi: 10.1021/ja00834a039.

引用本文的文献

1
Differential susceptibility of spleen focus-forming virus and murine leukemia viruses to ansamycin antibiotics.脾灶形成病毒和鼠白血病病毒对茴香霉素类抗生素的敏感性差异
Antimicrob Agents Chemother. 1977 Jul;12(1):4-10. doi: 10.1128/AAC.12.1.4.

本文引用的文献

1
Antivirion effects of streptovaricin complex against Friend virus.链黑菌素复合物对弗氏病毒的抗病毒体作用。
Antimicrob Agents Chemother. 1974 Nov;6(5):594-7. doi: 10.1128/AAC.6.5.594.
2
ASSAY FOR FRIEND LEUKEMIA VIRUS: RAPID QUANTITATIVE METHOD BASED ON ENUMERATION OF MACROSCOPIC SPLEEN FOCI IN MICE.Friend白血病病毒检测:基于小鼠脾脏肉眼可见病灶计数的快速定量方法。
Virology. 1964 Nov;24:513-8. doi: 10.1016/0042-6822(64)90199-0.
3
Streptovaricin. I. Discovery and biologic activity.链黑菌素。一、发现及生物活性。
Am Rev Tuberc. 1957 Apr;75(4):576-83. doi: 10.1164/artpd.1957.75.4.576.
4
Spleen focus formation by polycythemic strains of Friend leukemia virus.弗瑞德白血病病毒红细胞增多症毒株所致的脾灶形成
Proc Soc Exp Biol Med. 1968 Mar;127(3):900-4. doi: 10.3181/00379727-127-32831.
5
Inhibition of Poxvirus replication by streptovaricin.链黑菌素对痘病毒复制的抑制作用。
J Virol. 1970 Oct;6(4):485-91. doi: 10.1128/JVI.6.4.485-491.1970.
6
Selective inhibition by streptovaricin of splenomegaly induced Rauscher leukaemia by virus.链黑菌素对脾肿大诱导的劳斯氏白血病病毒的选择性抑制作用。
Nat New Biol. 1971 Aug;232(33):214-6. doi: 10.1038/newbio232214a0.
7
Streptovaricins inhibit focus formation by MSV (MLV) complex.链黑菌素可抑制MSV(MLV)复合物的集落形成。
Nat New Biol. 1971 Aug;232(33):212-4. doi: 10.1038/newbio232212a0.
8
Streptovaricins inhibit RNA dependent DNA polymerase present in an oncogenic RNA virus.链黑菌素可抑制致癌RNA病毒中存在的RNA依赖性DNA聚合酶。
Nature. 1971 Mar 26;230(5291):249-50. doi: 10.1038/230249a0.
9
Studies on antimicrobial substance B 44 P (streptovaricin) produced by a strain of actinomycetes. II. Microbiological and pharmacological studies.对一株放线菌产生的抗菌物质B 44 P(链黑菌素)的研究。II. 微生物学和药理学研究。
J Antibiot (Tokyo). 1968 Mar;21(3):209-21. doi: 10.7164/antibiotics.21.209.
10
Relative biological activities of individual streptovaricins and streptovaricin acetates.各链黑菌素及链黑菌素乙酸酯的相对生物活性。
Biochemistry. 1974 Feb 26;13(5):861-7. doi: 10.1021/bi00702a004.