Horoszewicz J S, Rinehart K L, Leong S S, Carter W A
Antimicrob Agents Chemother. 1975 Mar;7(3):281-4. doi: 10.1128/AAC.7.3.281.
Chromatographic fractionation of streptovaricin complex yields two stable components enriched (4- to 16-fold) in activity directed against the polycythemic strain of Friend virus; both components apparently contain no streptovaricins. When compared with their unfractionated parent streptovaricin complex, eight individual intact streptovaricins (A through G and J) show at least a 30-fold reduction in antiviral activity. These results further support the conclusion that the diversified biological properties of streptovaricin complex probably reside in different molecular structures.
对链黑菌素复合物进行色谱分离可得到两种稳定成分,它们针对弗氏病毒红细胞增多症菌株的活性增强(4至16倍);这两种成分显然都不含链黑菌素。与未分离的亲本链黑菌素复合物相比,8种单独完整的链黑菌素(A至G和J)的抗病毒活性至少降低了30倍。这些结果进一步支持了以下结论:链黑菌素复合物的多种生物学特性可能存在于不同的分子结构中。