Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Cell Metab. 2013 Jun 4;17(6):851-859. doi: 10.1016/j.cmet.2013.05.008.
Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes. Macrophages have been recognized for some time to be critical participants in obesity-induced inflammation of adipose tissue. Of late, a score of other cell types of the innate and adaptive arms of the immune system have been suggested to play a positive or negative role in adipose tissue infiltrates. This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies, and complexities; and puts forward a minimalist synthetic scheme.
内脏脂肪组织的慢性、低度炎症，以及全身性炎症，是肥胖症和 2 型糖尿病发病率近期惊人平行上升之间的关键环节。巨噬细胞一直被认为是肥胖引起的脂肪组织炎症的关键参与者。最近，许多其他先天和适应性免疫系统的细胞类型被认为在脂肪组织浸润中发挥积极或消极作用。本文回顾了这些新参与者的现有数据；讨论了实验中的不确定性、不一致性和复杂性；并提出了一个最小综合方案。
