固有免疫反应中代谢与自噬机制之间的关系。
The relationship between metabolism and the autophagy machinery during the innate immune response.
机构信息
Department of Immunology, St. Jude Children's Research Institute, Memphis, TN 38105, USA.
Department of Immunology, St. Jude Children's Research Institute, Memphis, TN 38105, USA.
出版信息
Cell Metab. 2013 Jun 4;17(6):895-900. doi: 10.1016/j.cmet.2013.05.012.
Abstract
The innate immune response is shaped by multiple factors, including both traditional autophagy and LC3-associated phagocytosis (LAP). As the autophagic machinery is engaged during times of nutrient stress, arising from scarcity or pathogens, we examine how autophagy, specifically LAP, and cellular metabolism together influence macrophage function and the innate immune response.
摘要
先天免疫反应受多种因素影响，包括传统自噬和 LC3 相关的吞噬作用 (LAP)。由于营养物质的匮乏或病原体的出现导致营养应激时，自噬机制被激活，我们研究了自噬，特别是 LAP 和细胞代谢如何共同影响巨噬细胞功能和先天免疫反应。
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