Department of Biomaterials and Bioengineering, Institute of Health Biosciences, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8504, Japan.
Acta Biomater. 2013 Sep;9(9):8449-53. doi: 10.1016/j.actbio.2013.05.028. Epub 2013 Jun 4.
Metal devices in the human body induce serious metal artifacts in magnetic resonance imaging (MRI). Metals artifacts are mainly caused by a volume magnetic susceptibility (χv) mismatch between a metal device and human tissue. In this research, Au-xPt-yNb alloys were developed for fabricating MRI artifact-free biomedical metal devices. The magnetic properties, hardness and phase constitutions of these alloys were investigated. The Au-xPt-8Nb alloys showed satisfactory χv values. Heat treatments did not clearly change the χv values for Au-xPt-8Nb alloys. The Vickers hardness (HV) of these two alloys was much higher than that of high-Pt alloys; moreover, aging at 700°C increased the HV values of these two alloys. A dual phase structure consisting of face-centered cubic α1 and α2 phases was observed and aging at 700°C promoted phase separation. The Au-5Pt-8Nb and Au-10Pt-8Nb alloys showed satisfactory χv values and high hardness and are thus suggested as candidates for MRI artifact-free alloys for biomedical applications.
人体内的金属器件会在磁共振成像(MRI)中产生严重的金属伪影。金属伪影主要是由于金属器件和人体组织之间的体积磁化率(χv)不匹配引起的。在这项研究中,开发了 Au-xPt-yNb 合金,用于制造无 MRI 伪影的生物医学金属器件。研究了这些合金的磁性、硬度和相组成。Au-xPt-8Nb 合金表现出令人满意的 χv 值。热处理对 Au-xPt-8Nb 合金的 χv 值没有明显影响。这两种合金的维氏硬度(HV)远高于高 Pt 合金;此外,在 700°C 时效处理会提高这两种合金的 HV 值。观察到由面心立方α1 和 α2 相组成的双相结构,700°C 时效处理促进了相分离。Au-5Pt-8Nb 和 Au-10Pt-8Nb 合金具有令人满意的 χv 值和高硬度,因此被认为是用于生物医学应用的无 MRI 伪影合金的候选材料。