盐酸卡替洛尔与脲诱导牛血清白蛋白相互作用的光谱研究。
Spectroscopic studies on the interaction of carteolol hydrochloride and urea-induced bovine serum albumin.
机构信息
Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2013 Sep;113:447-51. doi: 10.1016/j.saa.2013.04.129. Epub 2013 May 16.
The interaction of carteolol hydrochloride, to 0.2 mol L(-1) urea-induced bovine serum albumin in aqueous solution has been first investigated by fluorescence spectra and ultraviolet-visible (UV-vis) spectra at pH 7.40. The quenching mechanism, binding parameter and sites (n), the binding mode (ΔG, ΔH, and ΔS) as well as the binding distance (r) have been obtained according to the experimental results. We also use the synchronous fluorescence method to study the effect of CTL on the conformation change of urea-induced BSA.
盐酸卡替洛尔在 pH 7.40 时，首次通过荧光光谱和紫外-可见（UV-vis）光谱研究了其与 0.2 mol L(-1)尿素诱导的牛血清白蛋白在水溶液中的相互作用。根据实验结果，得出了猝灭机制、结合参数和结合位点数（n）、结合模式（ΔG、ΔH 和 ΔS）以及结合距离（r）。我们还使用同步荧光法研究了 CTL 对尿素诱导的 BSA 构象变化的影响。
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