Comprehensive Epilepsy Center, Department of Neurology, Northwestern University Feinberg School of Medicine, USA.
Epilepsy Behav. 2013 Aug;28(2):172-6. doi: 10.1016/j.yebeh.2013.04.017. Epub 2013 Jun 7.
The risk of sudden unexpected death in epilepsy (SUDEP) is highest with nocturnal, unattended generalized convulsions, and basic resuscitation may be able to prevent SUDEP. This study investigates an under-mattress device (ElectroMechanical Film - Emfit®) which is triggered by rhythmic motor activity of a specifiable duration, frequency, and intensity using a quasi-piezoelectric material sensitive to changes in mattress pressure. The device was tested during inpatient video-EEG monitoring. Eighteen GTCSs were recorded, 10 out of wakefulness and 8 out of sleep. Sixteen of the 18 seizures (89%) resulted in Emfit® activation with both false negative alarms occurring during wakefulness. On average, the device was activated within 9 s of onset of bilateral clonic motor movements (range: -37 to +39 s) and occurred, on average, 45 s before seizure end (range: 19 to 76 s). Only 21 false alarms were encountered, all occurring during wakefulness (PPV: 43%). The data suggest that the Emfit® detection device has a high predictive value for generalized convulsions, offers caregivers a reliable and early warning to assist the patient during convulsions, and may be a novel way to prevent SUDEP.
癫痫猝死（SUDEP）的风险最高，发生在夜间无人看管的全身性癫痫发作时，基本的复苏可能能够预防 SUDEP。本研究调查了一种床垫下设备（机电膜 - Emfit®），它通过使用对床垫压力变化敏感的准压电材料，根据指定的持续时间、频率和强度触发节律性运动活动。该设备在住院视频脑电图监测期间进行了测试。记录了 18 次全身性强直阵挛发作（GTCSs），10 次发生在清醒状态，8 次发生在睡眠中。18 次癫痫发作中的 16 次（89%）导致 Emfit®激活，两次假阴性警报均发生在清醒状态。平均而言，该设备在双侧阵挛性运动发作开始后 9 秒内激活（范围：-37 到+39 秒），并且在癫痫发作结束前平均发生 45 秒（范围：19 到 76 秒）。仅遇到 21 次假警报，均发生在清醒状态（PPV：43%）。数据表明，Emfit®检测设备对全身性癫痫发作具有很高的预测价值，为护理人员提供了可靠的早期预警，以在癫痫发作期间协助患者，并且可能是预防 SUDEP 的一种新方法。
