Limelette Anne, Boulagnon Camille, Terrade Caroline, N'guyen Yohan, Guillard Thomas, Andréoletti Laurent, Garnotel Roselyne, Digeon Béatrice, De Champs Christophe, Fornes Paul, Lévêque Nicolas
Laboratoire de bactériologie, CHU de Reims, France.
Ann Biol Clin (Paris). 2013 May-Jun;71(3):299-304. doi: 10.1684/abc.2013.0825.
The concept of sudden infant death syndrome (SIDS) is defined as the sudden, unexpected death of an infant less than a year old which remains unexplained after in-depth investigations comprising a complete autopsy, biological analyses, and a clinical examination of the circumstances surrounding the death. This definition underlines the importance of finding the cause of this disease in order to improve preventative measures to reduce the number of deaths due to sudden infant death syndrome. Among the causes of SIDS, pediatric infectious diseases may be neglected and must be systematically sought after. We report upon a SIDS death case of a four and a half month-old that occurred during his sleep. Following the absence of an evident cause of death a scientific autopsy was performed. The histological examination of pulmonary tissue revealed broncolitic lesions associated with numerous micro-abscesses. The post mortem microbiological analyses revealed evidence of an infection by the respiratory syncytial virus complicated by a bacterial infection due to Haemophilus influenzae. The case underlines the necessity of a multidisciplinary approach to researching SIDS, involving both clinicians and biologists, in order to determine the causes of these deaths.
婴儿猝死综合征（SIDS）的概念被定义为一岁以下婴儿的突然、意外死亡，在经过包括完整尸检、生物学分析以及对死亡周围情况的临床检查在内的深入调查后，死因仍无法解释。这一定义强调了找出该疾病病因对于改进预防措施以减少婴儿猝死综合征死亡人数的重要性。在婴儿猝死综合征的病因中，儿科传染病可能被忽视，必须进行系统排查。我们报告一例四个半月大婴儿在睡眠中发生的婴儿猝死综合征死亡病例。在未发现明显死因后，进行了科学尸检。肺组织的组织学检查显示有细支气管炎性病变并伴有大量微脓肿。死后微生物学分析显示有呼吸道合胞病毒感染的证据，并伴有因流感嗜血杆菌引起的细菌感染。该病例强调了采用多学科方法研究婴儿猝死综合征的必要性，临床医生和生物学家都应参与其中，以确定这些死亡的原因。
