Vikis Haris G, Rymaszewski Amy L, Tichelaar Jay W
Department of Pharmacology and Toxicology, Medical College of Wisconsin and MCW Cancer Center, Milwaukee, WI 53202, USA.
Front Biosci (Elite Ed). 2013 Jun 1;5(3):939-46. doi: 10.2741/e673.
Primary pulmonary malignancies remain the major source of cancer-related deaths in the Western World. While surgical resection is an efficacious therapy for those with early stage disease, the majority of patients present with advanced malignancies and systemic treatments, such as cytotoxic chemotherapy, have only limited efficacy in lung cancer. Furthermore, chemoprevention for current or former smokers has demonstrated only limited success using available agents. The mouse model of primary lung carcinogenesis represents a very valuable tool for the study of tumor initiation, promotion, and therapy. Here we discuss several models of chemically-induced murine lung cancer with a specific emphasis on translational and clinically-relevant lines of investigation. We emphasize the pros and cons of currently available models in order to facilitate further investigations into the development and treatment of primary pulmonary malignancies.
原发性肺恶性肿瘤仍然是西方世界癌症相关死亡的主要原因。虽然手术切除对于早期疾病患者是一种有效的治疗方法，但大多数患者就诊时已处于晚期恶性肿瘤阶段，而细胞毒性化疗等全身治疗在肺癌中的疗效有限。此外，使用现有药物对当前或既往吸烟者进行化学预防仅取得了有限的成功。原发性肺癌发生的小鼠模型是研究肿瘤起始、促进和治疗的非常有价值的工具。在此，我们讨论几种化学诱导的小鼠肺癌模型，特别强调转化研究和临床相关的研究方向。我们强调现有模型的优缺点，以便促进对原发性肺恶性肿瘤的发生和治疗的进一步研究。
