有机催化不对称远程氮丙啶化 2,4-二烯醛。
Organocatalytic asymmetric remote aziridination of 2,4-dienals.
机构信息
Center for Catalysis, Aarhus University, Langelandsgade 140, DK-8000 Aarhus C, Denmark.
出版信息
Chem Commun (Camb). 2013 Jul 21;49(57):6382-4. doi: 10.1039/c3cc43506g.
PMID:23748437
Abstract
Highly regio- and stereoselective remote aziridination of 2,4-dienals has been developed, based on a vinylogous iminium-ion-dienamine catalytic cascade reaction. Transformations of the aziridine products into enantioenriched motifs are also demonstrated. Furthermore, the reaction concept is extended to include enantioselective 1,6-addition of thiols.
摘要
基于乙烯基亚胺离子-烯胺催化级联反应，发展了高区域和立体选择性的 2,4-二烯醛的远程氮丙啶化反应。还展示了氮丙啶产物转化为对映体富集的结构单元。此外，该反应概念还扩展到包括硫醇的对映选择性 1,6-加成。
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