Rheumatology Section, Department of Medicine, University of Verona, Italy.
Calcif Tissue Int. 2013 Sep;93(3):249-52. doi: 10.1007/s00223-013-9750-6. Epub 2013 Jun 11.
We have recently reported a long-lasting decrease in circulating γδ T cells in osteoporotic patients on oral amino-bisphosphonates (N-BPs). Here we verify whether these changes are associated with the occurrence of acute phase response (APR) to intravenous (IV) zoledronic acid (ZOL) or changes of other circulating white blood cells (WBC). WBC count was obtained before and 1 year after a single IV administration of 5 mg ZOL in 36 osteoporotic patients (mean age 72 ± 9, range 45-86 years) without other relevant diseases; 12 of 36 patients developed the classical APR. After 1 year in the patients who experienced an APR, but not in the others, a significant decrease not only of γδ T cells (-30 %), but also of total lymphocytes (-11 %) and eosinophils (-27 %), was observed. The mechanism leading to the observed decrease of circulating lymphocytes and eosinophils remains unclear, but our observation opens a new frontier for the understanding of the immunoeffects of N-BPs.
我们最近报道了口服氨基双膦酸盐（N-BPs）治疗骨质疏松症患者后循环 γδ T 细胞持续减少。在这里，我们验证这些变化是否与静脉注射（IV）唑来膦酸（ZOL）的急性期反应（APR）的发生或其他循环白细胞（WBC）的变化有关。在没有其他相关疾病的情况下，36 名骨质疏松症患者（平均年龄 72±9 岁，范围 45-86 岁）单次静脉注射 5mg ZOL 前后获得了 WBC 计数；36 名患者中有 12 名发生了典型的 APR。在经历 APR 的患者中，经过 1 年，不仅 γδ T 细胞（-30%），而且总淋巴细胞（-11%）和嗜酸性粒细胞（-27%）明显减少。导致观察到的循环淋巴细胞和嗜酸性粒细胞减少的机制尚不清楚，但我们的观察为理解 N-BPs 的免疫作用开辟了新的领域。
