Josiassen R C, Roemer R A, Johnson M M, Shagass C
Medical College of Pennsylvania/EPPI, Philadelphia 19129.
Schizophr Bull. 1990;16(2):229-46. doi: 10.1093/schbul/16.2.229.
Numerous studies have reported relationships between gender and cerebral event-related potentials (ERPs) recorded from the human scalp. Recent studies have suggested that the influences of gender on ERPs may differ in persons with schizophrenia compared to healthy controls. In a further evaluation of the influences of this critical subject variable on ERP characteristics in schizophrenia, ERPs of age- and gender-matched groups (n = 72 each) of unmedicated schizophrenic patients and healthy controls were compared. ERPs elicited by left and right median nerve stimulation, checkerboard pattern visual flash, and auditory clicks were recorded from 15 scalp leads. The results confirm previous findings showing that: (1) number of comparable gender effects present in the ERP records of these two large study groups and (2) specific Diagnosis x Gender interactions suggesting that schizophrenic illness may modify normal gender influences on ERP characteristics. These data illustrate the point that matching schizophrenic patients and healthy control populations for gender is essential but not sufficient. Even in carefully matched groups, gender confounding can persist as a source of error variance because the influence can vary for different diagnostic groups.
众多研究报告了人类头皮记录的性别与大脑事件相关电位（ERP）之间的关系。近期研究表明，与健康对照相比，精神分裂症患者中性别对ERP的影响可能有所不同。在进一步评估这一关键受试者变量对精神分裂症患者ERP特征的影响时，比较了年龄和性别匹配组（每组n = 72）的未用药精神分裂症患者和健康对照的ERP。从15个头皮导联记录了由左右正中神经刺激、棋盘格视觉闪光和听觉咔哒声诱发的ERP。结果证实了先前的发现，即：（1）这两个大型研究组的ERP记录中存在相当数量的可比性别效应；（2）特定的诊断×性别相互作用表明，精神分裂症可能会改变正常性别对ERP特征的影响。这些数据表明，将精神分裂症患者和健康对照人群进行性别匹配至关重要，但并不充分。即使在精心匹配的组中，性别混杂也可能作为误差方差的一个来源持续存在，因为不同诊断组的影响可能不同。
