Orecchia Roberto, Srivastava Anurita, Fiore Maria Rosaria, Vitolo Viviana, Fossati Piero, Vischioni Barbara, Iannalfi Alberto, Tuan Jeffrey, Ciocca Mario, Molinelli Silvia, Mirandola Alfredo, Vilches Gloria, Mairani Andrea, Tagaste Barbara, Baroni Guido, Rossi Sandro, Krengli Marco
Fondazione CNAO, Pavia, Italy.
Tumori. 2013 Mar-Apr;99(2):e34-7. doi: 10.1177/030089161309900225.
Proton beam radiotherapy, an innovative treatment modality, allows delivery of high radiation doses to the target while sparing surrounding healthy structures. The Centro Nazionale di Adroterapia Oncologica (CNAO), equipped with a synchrotron and capable of using both protons and ions, initiated its clinical activity in September 2011. The first treatment of a skull base tumor with protons is reported here. The case of a 26-year-old man with an intracranial low-grade chondrosarcoma of the right petroclival junction is discussed with emphasis on technical and clinical details. Two previous surgical interventions had achieved partial removal of the tumor and the patient was treated with protons for residual disease. The prescribed dose was 70 GyE in 35 fractions of 2 GyE. Treatment was completed with minimal acute toxicity consisting of grade 1 alopecia and nausea. Nine months after treatment the disease is locally controlled. Use of high-energy protons at CNAO is a safe and effective means of treating a tumor located near critical normal structures.
质子束放射治疗是一种创新的治疗方式，能够在保护周围健康组织的同时，将高剂量辐射传递至靶区。位于意大利的国家肿瘤放疗中心（CNAO）配备了一台同步加速器，能够使用质子和离子，于2011年9月开展临床治疗。本文报道了首例使用质子治疗颅底肿瘤的病例。文中讨论了一名26岁男性患者，其右侧岩斜区交界处患有颅内低度软骨肉瘤，重点介绍了技术和临床细节。此前的两次手术仅部分切除了肿瘤，该患者接受质子治疗以处理残留病灶。处方剂量为70 GyE，分35次给予，每次2 GyE。治疗完成时急性毒性极小，仅出现1级脱发和恶心。治疗九个月后，疾病得到局部控制。在CNAO使用高能质子是治疗位于关键正常结构附近肿瘤的一种安全有效的方法。
