[Sicca syndrome in amyloidosis].

We report on two patients with rheumatoid arthritis and sicca syndrome due to secondary amyloidosis (A-amyloid) with involvement of the kidneys and gut. At autopsy, generalized amyloidosis was found with deposits in the salivary and lacrimal glands. Two other patients developed sicca syndrome due to primary systemic L-amyloidosis with Bence-Jones paraproteinuria, renal insufficiency and amyloid cardiomyopathy; both died of cardiac failure. Although sicca syndrome with amyloidosis has been described only occasionally, it is possible that this association is more frequent. These observations suggest that not only Sjögren's syndrome but also amyloidosis should be considered as a possible cause of sicca syndrome.