Martinović-Bevanda Anita, Radić Njegomir
Department of Chemistry, Faculty of Science and Education, University of Mostar, Bosnia and Herzegovina.
Anal Sci. 2013;29(6):669-71. doi: 10.2116/analsci.29.669.
A simple and sensitive spectrophotometric method, based on reaction between Ni(II) ion and D-penicillamine (PEN), was developed. The proposed SIA system enhanced the analytical applicability of the reaction of complexation, and allowed the determination of PEN in the concentration range of 3.0 × 10(-6) - 2.0 × 10(-4) mol L(-1) with a sampling rate of 200 h(-1). With the proposed SIA system, PEN could be accurately determinated up to 0.9 nmol quantity. The method was successfully applied to the determination of PEN in laboratory samples and pharmaceuticals.
基于镍（II）离子与D-青霉胺（PEN）之间的反应，开发了一种简单灵敏的分光光度法。所提出的顺序注射分析（SIA）系统提高了络合反应的分析适用性，能够在3.0×10⁻⁶ - 2.0×10⁻⁴ mol L⁻¹的浓度范围内以200 h⁻¹的采样速率测定PEN。使用所提出的SIA系统，PEN的准确测定量可达0.9 nmol。该方法已成功应用于实验室样品和药物中PEN的测定。
