基于与镍离子的络合反应，采用分光光度法顺序注射测定D-青霉胺。

Spectrophotometric sequential injection determination of D-penicillamine based on a complexation reaction with nickel ion.

作者信息

Martinović-Bevanda Anita, Radić Njegomir

机构信息

Department of Chemistry, Faculty of Science and Education, University of Mostar, Bosnia and Herzegovina.

出版信息

Anal Sci. 2013;29(6):669-71. doi: 10.2116/analsci.29.669.

DOI:10.2116/analsci.29.669

PMID:23749136

Abstract

A simple and sensitive spectrophotometric method, based on reaction between Ni(II) ion and D-penicillamine (PEN), was developed. The proposed SIA system enhanced the analytical applicability of the reaction of complexation, and allowed the determination of PEN in the concentration range of 3.0 × 10(-6) - 2.0 × 10(-4) mol L(-1) with a sampling rate of 200 h(-1). With the proposed SIA system, PEN could be accurately determinated up to 0.9 nmol quantity. The method was successfully applied to the determination of PEN in laboratory samples and pharmaceuticals.

摘要

基于镍（II）离子与D-青霉胺（PEN）之间的反应，开发了一种简单灵敏的分光光度法。所提出的顺序注射分析（SIA）系统提高了络合反应的分析适用性，能够在3.0×10⁻⁶ - 2.0×10⁻⁴ mol L⁻¹的浓度范围内以200 h⁻¹的采样速率测定PEN。使用所提出的SIA系统，PEN的准确测定量可达0.9 nmol。该方法已成功应用于实验室样品和药物中PEN的测定。