Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
Chem Soc Rev. 2013 Aug 21;42(16):6634-54. doi: 10.1039/c3cs60044k.
Dynamic covalent chemistry (DCvC) has been strongly integrated into diverse research fields, and has enabled easy access to a variety of combinatorial libraries, 2-D macrocycles, and 3-D molecular cages that target many important applications, such as drug discovery, biotechnology, molecular separation, light harvesting, etc. DCvC relies on the reversible formation and breaking of rather strong covalent bonding within molecules. Therefore it combines the error-correction capability of supramolecular chemistry and the robustness of covalent bonding. Compared to those supramolecular interactions, dynamic covalent reactions usually have slower kinetics and require the assistance of catalysts to achieve rapid equilibrium. Although the scope of dynamic covalent reactions is rapidly expanding, the reversible reactions suitable for DCvC are still very limited. The identification and development of new dynamic reactions and catalysts would be critical for the further advancement of DCvC. This review covers the recent development of dynamic covalent reactions as well as their applications.
动态共价化学（DCvC）已经被广泛应用于各个研究领域，并为多种组合文库、二维大环和三维分子笼的构建提供了便利，这些物质在药物发现、生物技术、分子分离、光捕获等领域有着广泛的应用。DCvC 依赖于分子内部强共价键的可逆形成和断裂。因此，它结合了超分子化学的纠错能力和共价键的坚固性。与那些超分子相互作用相比，动态共价反应通常具有较慢的动力学，需要催化剂的辅助才能达到快速平衡。尽管动态共价反应的范围正在迅速扩大，但适合 DCvC 的可逆反应仍然非常有限。识别和开发新的动态反应和催化剂对于 DCvC 的进一步发展至关重要。本综述涵盖了动态共价反应的最新发展及其应用。
