Department of Medicine (A.H.), Mayo School of Graduate Medical Education, Rochester, MN, USA.
Curr Infect Dis Rep. 2013 Aug;15(4):347-52. doi: 10.1007/s11908-013-0347-z.
Despite advances in medical and surgical management, infective endocarditis remains associated with significant morbidity and mortality. Septic embolization to the brain and other organs is one of the most dreaded complications of infective endocarditis. Given the critical role of platelets in bacterial vegetation formation on cardiac valves or cardiac device leads, antiplatelet agents, including aspirin, have recently generated much interest as adjunctive therapies in cardiovascular infections. In this article, we review the published evidence evaluating the role of platelets in the pathogenesis of cardiovascular infections and the rationale for using antiplatelet agents in these infections.
尽管在医学和外科治疗方面取得了进展，但感染性心内膜炎仍然与较高的发病率和死亡率相关。感染性心内膜炎最可怕的并发症之一是感染性栓子向大脑和其他器官的转移。鉴于血小板在心脏瓣膜或心脏器械导线上的细菌生物膜形成中的关键作用，抗血小板药物，包括阿司匹林，最近作为心血管感染的辅助治疗引起了广泛关注。在本文中，我们回顾了评估血小板在心血管感染发病机制中的作用的已发表证据，以及在这些感染中使用抗血小板药物的原理。
