Yu C Y, Xu S T, Ou Y Q
Neurophysiology Research Laboratory, South China Normal University, Guangzhou.
Sheng Li Xue Bao. 1990 Apr;42(2):194-7.
Population spikes were recorded from hippocampal CA3 of freely moving rats following stimulation of the perforant path. Six rats were trained to perform conditioned drinking behavior. (1) Animals were treated with electroshock in less than 15 minutes after daily training session for a period of 6 consecutive days. Synaptic efficacy did not increase and the conditioned response could not be established during the behavioral training in four rats, synaptic efficacy was increased, the long-term potentiation (LTP) appeared and the conditioned behavior was established in other two rats. (2) After consolidation of conditioned behavior, electroshock temporarily caused suppression of the learning-dependent LTP and the correlative conditioned response. Both LTP and the correlative conditioned response recovered in one to four hours after electroshock. In these cases, the maximal development of LTP preceded the development of conditioned behavior. The results indicated that the learning-dependent LTP might be one of the neural substrates underlying learning and memory.
在自由活动的大鼠海马CA3区记录到了在穿通路径受到刺激后的群体放电峰值。六只大鼠被训练执行条件性饮水行为。（1）在每日训练结束后不到15分钟内，对动物进行电击，持续6天。在四只大鼠的行为训练过程中，突触效能未增加，条件反应无法建立；而在另外两只大鼠中，突触效能增加，出现了长时程增强（LTP），并且建立了条件行为。（2）在条件行为巩固后，电击暂时抑制了依赖学习的LTP和相关的条件反应。电击后1至4小时，LTP和相关的条件反应均恢复。在这些情况下，LTP的最大发展先于条件行为的发展。结果表明，依赖学习的LTP可能是学习和记忆的神经基础之一。
