Küçük Oznur, Biçer Suat, Giray Tuba, Cöl Defne, Erdağ Gülay Ciler, Gürol Yeşim, Kaspar Ciğdem E, Vitrinel Ayça
Department of Child Health and Diseases, Faculty of Medicine, Yeditepe University, Devlet Yolu, Ankara Cad. No: 102-104, Ataşehir, 34752, Istanbul, Turkey,
Indian J Pediatr. 2014 Feb;81(2):138-42. doi: 10.1007/s12098-013-1067-y. Epub 2013 Jun 8.
To evaluate the utility of rapid antigen detection testing (RADT) for the diagnosis of group A beta-hemolytic streptococcal tonsillopharyngitis in children, and to detect the sensitivity and specificity of rapid antigen detection of group A beta-hemolytic streptococci from throat specimen compared with throat culture.
Rapid antigen detection and throat culture results for group A beta-hemolytic streptococci from outpatients attending university hospital between 1st January 2011 and 31st of December 2011 were evaluated retrospectively. The antigen test negative-throat culture positive patients were investigated for streptococcal carriage. For this purpose, the throat culture results taken from these patients were reviewed after treatment.
Eight hundred and ninetytwo children were included in the studywith a mean age of 5.34 y. There were 639 and 253 children in two groups with age of 0-6 and 7-17 y, RADT sensitivity and specificity were found to be 59.5 % and 97.2 %, respectively. The positive predictive value was 87.1 %, whereas negative predictive value was 88.4 %. After treatment of 74 patients with throat culture positive and antigen test negative. Group A beta-hemolytic streptococci were isolated in 12 of them (16.2 %) and accepted as a carrier.
The low sensitivity of the RADT may be related to streptococcal carriage in some patients. The throat culture should be repeated after treatment to detect streptococcal carriage.
评估快速抗原检测试验（RADT）在诊断儿童A组β溶血性链球菌扁桃体咽炎中的效用，并检测与咽拭子培养相比，从咽拭子标本中快速检测A组β溶血性链球菌的敏感性和特异性。
回顾性评估2011年1月1日至2011年12月31日在大学医院就诊的门诊患者A组β溶血性链球菌的快速抗原检测和咽拭子培养结果。对抗原检测阴性但咽拭子培养阳性的患者进行链球菌携带情况调查。为此，在治疗后复查这些患者的咽拭子培养结果。
892名儿童纳入研究，平均年龄5.34岁。0至6岁和7至17岁两组分别有639名和253名儿童，RADT的敏感性和特异性分别为59.5%和97.2%。阳性预测值为87.1%，阴性预测值为88.4%。对74名咽拭子培养阳性但抗原检测阴性的患者进行治疗后，其中12名（16.2%）分离出A组β溶血性链球菌，被视为携带者。
RADT的低敏感性可能与部分患者的链球菌携带有关。治疗后应重复咽拭子培养以检测链球菌携带情况。
