β-葡聚糖信号连接吞噬作用和自噬作用。
β-Glucan signaling connects phagocytosis to autophagy.
机构信息
Research Division of Immunology, Department of Biomedical Sciences, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
出版信息
Glycobiology. 2013 Sep;23(9):1047-51. doi: 10.1093/glycob/cwt046. Epub 2013 Jun 6.
Abstract
A growing list of innate immune receptors is being defined that recognize polysaccharides of microbial cell walls. Fungal β-glucan recognition by the receptor Dectin-1 triggers inflammatory immune responses in macrophages and dendritic cells that are appropriate for defense against fungal pathogens. Among these responses is the specific recruitment of the autophagy-related protein light chain 3 (LC3) to phagosomes containing fungi. Studies documenting LC3's recruitment to phagosomes containing β-glucan and other nonsugar particles suggest that LC3 plays a role in regulating phagocytosis and its related immunological responses.
摘要
越来越多的先天免疫受体被定义为能够识别微生物细胞壁多糖的受体。受体 Dectin-1 识别真菌β-葡聚糖，触发巨噬细胞和树突状细胞的炎症免疫反应，这是防御真菌病原体的适当反应。在这些反应中，特定的自噬相关蛋白轻链 3（LC3）被招募到含有真菌的吞噬体中。有研究记录了 LC3 被招募到含有β-葡聚糖和其他非糖颗粒的吞噬体中，这表明 LC3 在调节吞噬作用及其相关免疫反应中发挥作用。
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