Velichkovskiĭ B T, Cheremisina Z P, Korkina L G, Suslova T B, Mal'tseva L M, Finkel'berg E I
Sov Med. 1990(4):14-6.
Blood leukocyte function in patients with silicosis and chronic dust-induced bronchitis was examined by cellular chemiluminescence method for registration of free oxygen radical production. Significant differences in oxidation metabolism of blood neutrophils in the patients with these two nosologic entities were revealed. In silicosis blood phagocyte activation with silica particles in vitro activated production of active oxygen forms and chemiluminescent cells in all cases by 3 to 30 times. In chronic dust-induced bronchitis the production of active oxygen forms under the same conditions was either unchanged or enhanced but negligibly, the activation coefficient not surpassing 3. These data point to a new approach to the differential diagnosis between the above-mentioned conditions.
采用细胞化学发光法检测矽肺和慢性粉尘性支气管炎患者的血液白细胞功能，以记录游离氧自由基的产生。结果显示，这两种疾病患者的血液中性粒细胞氧化代谢存在显著差异。在矽肺患者中，体外二氧化硅颗粒激活血液吞噬细胞后，活性氧形式和化学发光细胞的产生在所有情况下均增加3至30倍。在慢性粉尘性支气管炎患者中，相同条件下活性氧形式的产生要么未改变，要么仅略有增加，激活系数不超过3。这些数据为上述疾病的鉴别诊断提供了新方法。
