Perederiĭ V G, Tkach S M, Bychkova N G, Blazhenko I L
Sov Med. 1990(4):17-9.
Clinical and immunologic efficacies of some immunostimulants (levamisole, sodium nucleinate, thymic preparations) included in therapeutic schemes in nonspecific ulcerous colitis both separately and in various combinations were under study. The efficacy of these stimulants was found to depend on the disease severity and proved to be the highest in the light course. Thymalin and sodium nucleinate showed the highest clinical and immunologic efficacies, particularly if used together. Levamisole administration was associated with frequent side effects and had no essential advantages over basic therapy. This permits a conclusion that immunostimulants are pathogenetically validated in therapy of ulcerous colitis, for they result in reduction or elimination of immunity insufficiency and their administration leads to a positive clinical effect in the majority of cases.
正在研究治疗方案中所包含的某些免疫刺激剂（左旋咪唑、核酸钠、胸腺制剂）单独使用及各种组合使用时对非特异性溃疡性结肠炎的临床和免疫疗效。发现这些刺激剂的疗效取决于疾病的严重程度，且在轻症病程中疗效最高。胸腺素和核酸钠显示出最高的临床和免疫疗效，尤其是一起使用时。使用左旋咪唑常伴有副作用，与基础治疗相比并无本质优势。由此可以得出结论，免疫刺激剂在溃疡性结肠炎治疗中在发病机制上是有效的，因为它们能减少或消除免疫功能不全，并且在大多数情况下给药会产生积极的临床效果。
