Balabolkin M I, Gerasimov G A, Gorokhova T R, Liubimov A V
Sov Med. 1990(4):23-6.
A total of 122 male subjects suffering from secretory infertility were examined. In 25 of them (20 percent) blood prolactin levels were above the norm. Measurements of basal prolactin levels and of its secretion in metoclopramide test helped distinguish two types of hyperprolactinemia syndrome, differing in the pattern of spermatogenesis disorders. Possible pathogenesis of individual types of hyperprolactinemia in men is discussed. Therapy with dopamine agonists (lisenyl, parlodel) was found most effective in Type I hyperprolactinemia syndrome, associated with essential prolactin hypersecretion and oligospermia.
对122名患有分泌性不育症的男性受试者进行了检查。其中25人(20%)的血催乳素水平高于正常范围。通过测定基础催乳素水平及其在甲氧氯普胺试验中的分泌情况,有助于区分两种高催乳素血症综合征,它们在精子发生障碍模式上有所不同。文中讨论了男性个体类型高催乳素血症的可能发病机制。发现多巴胺激动剂(利舍尼、溴隐亭)治疗对I型高催乳素血症综合征最为有效,该综合征与原发性催乳素分泌过多和少精子症相关。