Department of Medicine, Molecular Pharmacology and Physiology, James A. Haley VA Medical Center and University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.
Anticancer Res. 2013 Jun;33(6):2409-14.
β-Catenin causes malignant growth of colonic, pancreatic and renal cancer. Four cardiac hormones, namely atrial natriuretic peptide (ANP), vessel dilator, long-acting natriuretic peptide (LANP) and kaliuretic peptide eliminate up to 80% of human pancreatic carcinomas growing in mice.
Four cardiac hormones were evaluated for their ability to reduce the expression of human β-catenin, measured by enzyme-linked immunosorbent assay (ELISA) in human colorectal, pancreatic and renal cancer cells.
Vessel dilator, LANP, kaliuretic peptide, and ANP, over a concentration range of 100 pM to 10 μM, maximally reduced expression of β-catenin in human colorectal cancer cells by 78%, 71%, 69%, and 83%, respectively. Vessel dilator, LANP, kaliuretic peptide, and ANP reduced β-catenin expression in human pancreatic cancer cells by 76%, 66%, 72%, and 88%, and by 64%, 54%, 58% and 73%, in human renal cancer cells, respectively.
Part of the anticancer action of these four cardiac hormones is a potent inhibition of β-catenin.
β-连环蛋白导致结肠、胰腺和肾癌的恶性生长。四种心脏激素，即心房利钠肽（ANP）、血管扩张剂、长效利钠肽（LANP）和利钾肽，可消除高达 80%在小鼠中生长的人类胰腺癌。
评估了四种心脏激素降低人结直肠、胰腺和肾癌细胞中β-连环蛋白表达的能力，通过酶联免疫吸附试验（ELISA）测量。
血管扩张剂、LANP、利钾肽和 ANP 在 100 pM 至 10 μM 的浓度范围内，分别将人结直肠癌细胞中β-连环蛋白的表达最大降低了 78%、71%、69%和 83%。血管扩张剂、LANP、利钾肽和 ANP 分别将人胰腺癌细胞中的β-连环蛋白表达降低了 76%、66%、72%和 88%，并将人肾癌细胞中的β-连环蛋白表达降低了 64%、54%、58%和 73%。
这四种心脏激素的部分抗癌作用是对β-连环蛋白的强烈抑制。
