Wieland E, Walli A K, Niedmann P D, Lohstöter C, Kraemer A, Seidel D
Abteilung für klinische Chemie der Universität Göttingen.
Ther Umsch. 1990 Jun;47(6):492-8.
We have studied the metabolism of post-prandial lipoproteins in four male patients who suffered from premature (less than 60 years) angiographically proven coronary heart disease. They had normal to low total and low density lipoprotein cholesterol levels. Other risk factors were absent. Using the vitamin A fat loading test we were able to show that the clearance of chylomicron remnants was delayed compared to three healthy control subjects. Since these postprandial lipoproteins have been implicated in atherogenesis, we conclude that this defect contributed to the development of coronary heart disease in these patients.
我们研究了4名男性患者餐后脂蛋白的代谢情况，这些患者患有早发性（小于60岁）经血管造影证实的冠心病。他们的总胆固醇和低密度脂蛋白胆固醇水平正常至偏低。不存在其他风险因素。通过维生素A脂肪负荷试验，我们发现与3名健康对照者相比，乳糜微粒残粒的清除延迟。由于这些餐后脂蛋白与动脉粥样硬化的发生有关，我们得出结论，这种缺陷促成了这些患者冠心病的发展。
