Du J, Fan Z, Ma X, Wu Y, Liu S, Gao Y, Shen Y, Fan M, Wang S
Molecular Laboratory for Gene Therapy & Tooth Regeneration, Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology , Tian Tan Xi Li No.4, Beijing 100050.
Biotech Histochem. 2014 Jan;89(1):14-8. doi: 10.3109/10520295.2013.795661. Epub 2013 Jun 10.
Dipeptidyl peptidase-like protein 6 (DPP6), a member of the dipeptidyl aminopeptidase family, plays distinct roles in brain development, but its expression in embryonic Meckel's cartilage and tooth germs development is unknown. We analyzed the expression pattern of DPP6 in Meckel's cartilage and tooth germs development using in situ hybridization. DPP6 was detected in different patterns in Meckel's cartilage and tooth germs during mouse facial development from 11.5 to 13.5 days post-coitus (dpc) embryos. The expression pattern of DPP6 suggests that it may be involved in mandible and tooth development.
二肽基肽酶样蛋白6（DPP6）是二肽基氨基肽酶家族的成员，在大脑发育中发挥着独特作用，但其在胚胎期梅克尔软骨和牙胚发育中的表达尚不清楚。我们采用原位杂交技术分析了DPP6在梅克尔软骨和牙胚发育中的表达模式。在交配后11.5至13.5天（dpc）胚胎的小鼠面部发育过程中，DPP6在梅克尔软骨和牙胚中呈现出不同的表达模式。DPP6的表达模式表明它可能参与下颌骨和牙齿的发育。
