Eleuteri C, Montes P, Rizzardini M
Bol Med Hosp Infant Mex. 1975 May-Jun;32(3):513-25.
In nine critically ill newborns, five of them with intractable diarrhea and four surgical patients, we administered a 5% crystalline aminoacids solution (AA) and glucose in sufficient amount to provide 120 cal times kg. in 24 hours. Six of them recovered after receiving parenteral alimentation for 3 to 15 days, gained weight during or after treatment and were discharged from the hospital in good conditions. Three died, one of them presented septicemia and two pneumonia and pulmonary infarcts. The solution used generated few metabolic alterations, the acid-base status remained within normal range and there were not important changes in the sodium and potassium serum concentrations. On the contrary, children with hyponatremia and hypokalemia at the beginning of the treatment, normalized these constants within the first hours, as diarrhea ceased. The most frequent complications were infiltrations and reaction of the surrounding tissue of the catheterized vein and local skin infection. Only one patient died of septicemia, possibly caused by this proceeding. In summary, parenteral alimentation though not free from risk, seems to be a useful proceeding when oral feeding is impossible or inadvisable. The utmost danger is septicemia. Metabolic changes are minimal and they do not mean a risk for child's life; nevertheless, there is a need for long term studies to bring up definite conclusions. The solutions in actual use are probably not the most physiological for the newborn. It is necessary to adequate them according to the new advances made on child nourishment during his first days of life.
在9名危重新生儿中,其中5名患有顽固性腹泻,4名是外科手术患者,我们给予了5%的结晶氨基酸溶液(AA)和足量葡萄糖,以在24小时内提供120千卡/千克的能量。其中6名患儿在接受肠外营养3至15天后康复,在治疗期间或治疗后体重增加,并顺利出院。3名患儿死亡,其中1名患有败血症,2名患有肺炎和肺梗死。所使用的溶液几乎没有引起代谢改变,酸碱状态保持在正常范围内,血清钠和钾浓度也没有显著变化。相反,治疗开始时患有低钠血症和低钾血症的患儿,随着腹泻停止,在最初几个小时内这些指标就恢复了正常。最常见的并发症是插管静脉周围组织的浸润和反应以及局部皮肤感染。只有1名患者死于败血症,可能是由该治疗过程引起的。总之,肠外营养虽然并非没有风险,但在无法进行或不宜进行口服喂养时似乎是一种有用的治疗方法。最大的危险是败血症。代谢变化很小,对患儿生命不构成风险;然而,需要进行长期研究才能得出明确结论。目前实际使用的溶液可能并非对新生儿最具生理性。有必要根据新生儿出生头几天儿童营养方面的新进展对其进行调整。