Coleman A J, Walling P T, Downing J W, Bees L T
Br J Anaesth. 1975 Mar;47(3):365-9. doi: 10.1093/bja/47.3.365.
The influence of carbon dioxide on the neuromuscular and haemodynamic effects of AH 8165, a new non-depolarizing muscle relaxant, was determined in nine healthy patients before the onset of minor elective surgery. Five patients (hypocapnic, group I) were maintained at an arterial Pco2 ranging from 25 to 31 mm Hg; four patients (hypercapnic, group II) at a Cco2 from 54 to 57 mm Hg. AH 8165 0.25 MG/KG (one-quarter of the dose required for intubation) was given by rapid central venous injection. Haemodynamic responses were similar in the two groups; there were increases in heart rate ranging from 45 to 60 per cent, increases in mean arterial pressure of 17 - 20 percent, and increases in cardiac output of 22-32 per cent. The intensity of neuromuscular blockade of the forearm muscles after AH 8165 was similar in the two groups, and there was no significant difference in recovery rates; group I patients were 80 percent recovered in 36.6 min. group II patients in 47.3 min. It was concluded that the activity of AH 8165 was not influenced by moderate changes in respiratory acid base status.
在九名择期小手术患者术前，研究了二氧化碳对新型非去极化肌松药AH 8165神经肌肉及血流动力学效应的影响。五名患者（低碳酸血症组，I组）动脉血二氧化碳分压维持在25至31毫米汞柱；四名患者（高碳酸血症组，II组）动脉血二氧化碳分压维持在54至57毫米汞柱。通过快速中心静脉注射给予AH 8165 0.25毫克/千克（插管所需剂量的四分之一）。两组的血流动力学反应相似；心率增加45%至60%，平均动脉压升高17% - 20%，心输出量增加22% - 32%。AH 8165给药后，两组前臂肌肉神经肌肉阻滞强度相似，恢复率无显著差异；I组患者在36.6分钟时恢复80%，II组患者在47.3分钟时恢复80%。得出结论，呼吸酸碱状态的适度变化不影响AH 8165的活性。
