Shiffrin Nina D, Gruber June, Glatt Stephen J, Faraone Stephen V
Department of Psychology, Yale University, New Haven, Connecticut, USA.
Psychiatr Genet. 2013 Aug;23(4):174-5. doi: 10.1097/YPG.0b013e3283631509.
There is evidence for a genetic contribution to attention-deficit hyperactivity disorder (ADHD), although no candidate genes have attained genome-wide significance to date. Given that the noradrenergic system has been implicated in ADHD, the gene for the α2-adrenergic receptor (ADRA2A) has been hypothesized to contribute to the pathogenesis of ADHD. The present investigation reports results from a meta-analysis of family-based studies that did not find a significant association between the MspI polymorphism of the ADRA2A gene and ADHD.
有证据表明基因对注意力缺陷多动障碍（ADHD）有影响，尽管迄今为止尚无候选基因达到全基因组显著性水平。鉴于去甲肾上腺素能系统与ADHD有关，有人提出α2-肾上腺素能受体（ADRA2A）基因可能参与ADHD的发病机制。本研究报告了一项基于家系研究的荟萃分析结果，该分析未发现ADRA2A基因的MspI多态性与ADHD之间存在显著关联。
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