Sweeney T E, Sarelius I H
Department of Biophysics, University of Rochester, School of Medicine and Dentistry, New York 14642.
Am J Physiol. 1990 Jul;259(1 Pt 2):H124-36. doi: 10.1152/ajpheart.1990.259.1.H124.
Spatial variations in microvascular function are described at two tissue sites in hamster cremaster muscle (pentobarbital sodium, 70 mg/kg ip). Arterioles observed include terminal arterioles and their feeding vessels, termed capillary network controllers (CNC). Although terminal arterioles at both sites had similar maximum diameters and cell flows, those at site I were significantly more constricted at rest (2.7 +/- 0.3 vs. 5.1 +/- 0.3 microns at site II) and showed lower resting flows (19.0 +/- 5.5 vs. 174 +/- 34 cells/s at site II). There were no spatial differences in CNC maximal parameters or CNC resting tone, yet CNC resting flow at site II (798 +/- 118 cells/s) significantly exceeded the value at site I (460 +/- 85 cells/s). At rest, median capillary cell flow at site I (3.3 cells/s) was half that at site II (6.3 cells/s). During hyperemia, perfused capillary segment length per unit volume was 84% greater at site I and estimated tissue erythrocyte content nearly double that at site II. Thus significant spatial differences in microvascular function exist in cell flow and vessel tone among terminal arterioles, in cell flow among CNC, and in capillarity and indices of capillary exchange.
在仓鼠提睾肌的两个组织部位（腹腔注射70mg/kg戊巴比妥钠）描述了微血管功能的空间差异。观察到的小动脉包括终末小动脉及其供血血管，即毛细血管网控制器（CNC）。尽管两个部位的终末小动脉具有相似的最大直径和细胞流量，但部位I的终末小动脉在静息时显著收缩更明显（部位I为2.7±0.3微米，部位II为5.1±0.3微米），且静息流量更低（部位I为19.0±5.5个细胞/秒，部位II为174±34个细胞/秒）。CNC的最大参数或CNC的静息张力没有空间差异，但部位II的CNC静息流量（798±118个细胞/秒）显著超过部位I的值（460±85个细胞/秒）。静息时，部位I的毛细血管中位数细胞流量（3.3个细胞/秒）是部位II（6.3个细胞/秒）的一半。在充血期间，单位体积内灌注的毛细血管段长度在部位I比部位II大84%，并且估计的组织红细胞含量几乎是部位II的两倍。因此，在终末小动脉之间的细胞流量和血管张力、CNC之间的细胞流量以及毛细血管形成和毛细血管交换指数方面，微血管功能存在显著的空间差异。
