Yang Ping, Li Xiaoyu, Zhang Ruili, Liu Ning, Zhang Yulan
School of Material Science and Engineering, University of Jinan, 250022 Jinan, PR China.
J Nanosci Nanotechnol. 2013 Mar;13(3):1784-8. doi: 10.1166/jnn.2013.7121.
Sol-gel procedures have been developed to encapsulate inorganic nanocrystals including metallic Au and II-VI semiconductor materials (CdSe/Cd(1-x)Zn(x)S) in SiO2 particles by using tetraethyl orthosilicate. The key strategy was the control of a sol-gel procedure. The anisotropic deposition of SiO2 monomers occurs because well-developed crystal facets having different affinity to SiO2 monomers. SiO2 monomers were not homogeneously deposited on nonspherical Au and CdSe/Cd(1-x)Zn(x)S nanocrystals. A surface silanization process, partly hydrolyzed tetraethyl orthosilicate were attached to the nanocrystals instead of initial ligands, plays an important role for the nanocrystals coated homogeneously with a SiO2 layer. Furthermore, CdSe/Cd(1-x)Zn(x)S nanocrystals were homogeneously coated with a thin SiO2 layer by the surface silanization process and a subsequent reverse micelle route. Colloidal Au nanocrystals were homogeneously coated with a SiO2 shell by the surface silanization process and subsequent Stöber synthesis without using a silane coupling agent or bulk polymer as the surface primer to render the Au surface vitreophilic. These results indicated partly hydrolyzed tetraethyl orthosilicate has an ability to replace the ligand on nanocrystals. After surface modification, the SiO2 particles with nanocrystals were conjugated with antibody for bioapplications.
已开发出溶胶-凝胶工艺，通过使用正硅酸四乙酯，将包括金属金和II-VI族半导体材料（CdSe/Cd(1-x)Zn(x)S）在内的无机纳米晶体封装在二氧化硅颗粒中。关键策略是控制溶胶-凝胶工艺。二氧化硅单体的各向异性沉积是因为发育良好的晶面与二氧化硅单体具有不同的亲和力。二氧化硅单体不会均匀地沉积在非球形的金和CdSe/Cd(1-x)Zn(x)S纳米晶体上。表面硅烷化过程，即部分水解的正硅酸四乙酯附着在纳米晶体上而非初始配体，对于用二氧化硅层均匀包覆纳米晶体起着重要作用。此外，通过表面硅烷化过程和随后的反胶束途径，CdSe/Cd(1-x)Zn(x)S纳米晶体被均匀地包覆上一层薄的二氧化硅层。通过表面硅烷化过程和随后的斯托伯合成法，在不使用硅烷偶联剂或本体聚合物作为表面底漆以使金表面亲玻璃的情况下，胶体金纳米晶体被均匀地包覆上二氧化硅壳层。这些结果表明部分水解的正硅酸四乙酯有能力取代纳米晶体上的配体。表面改性后，带有纳米晶体的二氧化硅颗粒与抗体结合用于生物应用。
