Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Crit Rev Oncol Hematol. 2013 Nov;88(2):447-58. doi: 10.1016/j.critrevonc.2013.05.005. Epub 2013 Jun 5.
The concept of larynx preservation in locally advanced laryngeal or hypopharyngeal squamous cell carcinoma has evolved during the last three decades, especially with the advancement of nonsurgical strategies. These nonsurgical strategies include: (1) radiotherapy alone; (2) concomitant chemoradiotherapy (CCRT); and (3) induction chemotherapy followed by radiotherapy or CCRT and concurrent anti-epidermal growth factor receptor (EGFR). To date, the best approach for larynx preservation has yet to be defined. In this article, we review and discuss important recent randomized phase II/III trials investigating larynx preservation in order to facilitate the selection of an appropriate strategy in the clinical setting. However, the decision of larynx preservation should always be a multidisciplinary approach.
在过去的三十年中，局部晚期喉或下咽鳞状细胞癌的喉保留概念不断发展，尤其是随着非手术策略的进步。这些非手术策略包括：（1）单纯放疗；（2）同期放化疗（CCRT）；（3）诱导化疗后放疗或 CCRT 联合抗表皮生长因子受体（EGFR）。迄今为止，尚未确定最佳的喉保留方法。在本文中，我们回顾和讨论了最近的重要随机 II/III 期临床试验，以探讨喉保留，以便在临床实践中选择合适的策略。然而，喉保留的决策始终应该是多学科的方法。
