Bioinformatics Centre, Bose Institute, P 1/12, C.I.T. Scheme VII M, Kolkata 700 054, India.
FEBS Lett. 2013 Jul 11;587(14):2284-7. doi: 10.1016/j.febslet.2013.05.062. Epub 2013 Jun 10.
Most proteins carry out their functions by participating in protein complexes. Recently, miRNAs were identified as promising post-transcriptional regulators that influence a large proportion of genes in higher eukaryotes. We aim to understand the role of miRNAs in the regulation of human proteins that are present in protein complexes. Here, we show that robust regulation by miRNA is absent in human complex-forming proteins. Moreover, the numbers of miRNA hits cannot direct the evolutionary fate of complex-forming proteins independently. However, the duplicated complex-forming proteins having a severe effect on organismal fitness are profoundly targeted by miRNA, probably to reduce the chances of dosage imbalance.
大多数蛋白质通过参与蛋白质复合物来执行其功能。最近，miRNA 被鉴定为有前途的转录后调控因子，影响高等真核生物中很大比例的基因。我们旨在了解 miRNA 在调节存在于蛋白质复合物中的人类蛋白质中的作用。在这里，我们表明 miRNA 在人类形成复合物的蛋白质中不存在稳健的调节作用。此外，miRNA 命中的数量不能独立地指导形成复合物的蛋白质的进化命运。然而，对生物体适应性有严重影响的复制形成复合物的蛋白质受到 miRNA 的深度靶向，可能是为了降低剂量失衡的机会。
