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独居与日本男性未确诊糖尿病的关系:糖尿病的可改变危险因素的作用:虎之门医院健康管理中心研究 13 项(TOPICS 13)。

Association of living alone with the presence of undiagnosed diabetes in Japanese men: the role of modifiable risk factors for diabetes: Toranomon Hospital Health Management Center Study 13 (TOPICS 13).

机构信息

Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata; Health Management Center, Toranomon Hospital, Tokyo; Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, Ibaraki.

出版信息

Diabet Med. 2013 Nov;30(11):1355-9. doi: 10.1111/dme.12255. Epub 2013 Jul 9.

Abstract

AIMS

To investigate whether living alone was associated with the presence of undiagnosed diabetes and whether this association could be attenuated by modifiable lifestyle habits.

METHODS

This cross-sectional study included 6400 Japanese men without a history of diagnosed diabetes. Individuals with currently undiagnosed diabetes were identified through fasting glucose concentration ≥7.0 mmol/l or HbA1c concentration ≥ 48 mmol⁄mol (≥ 6.5%). Effect modification was examined using body mass index, hypertension, history of dyslipidaemia, drinking habits, smoking habits, physical activity, vegetable intake, emotional stress and depressed mood.

RESULTS

Men who lived alone (n = 1098) had a significantly elevated odds ratio for having undiagnosed diabetes in an age-adjusted model (odds ratio 1.45, 95% CI 1.07, 1.96; P = 0.018). After adjustment for lifestyle factors, the association was slightly attenuated (odds ratio 1.40, 95% CI 1.02, 1.91; P = 0.036). After further adjustment for all factors mentioned above, living alone was still marginally significantly associated with the presence of undiagnosed diabetes (odds ratio 1.38, 95% CI 1.003, 1.90; P = 0.048). A significant association of living alone with the presence of undetected diabetes was particularly observed among men who were overweight, currently smoked and were physically inactive, or had any one of those three factors.

CONCLUSIONS

The association between undiagnosed diabetes and living alone can be partially influenced by modifiable lifestyle factors. Men who lived alone, especially those who did not engage in favourable lifestyle habits, were more likely to have undiagnosed diabetes. Such individuals have a higher probability of having undetected diabetic hyperglycaemia and would need to undergo glucose tests to identify the disease.

摘要

目的

研究独居是否与未诊断的糖尿病有关,以及这种关联是否可以通过可改变的生活方式习惯来减弱。

方法

这项横断面研究纳入了 6400 名无糖尿病诊断史的日本男性。通过空腹血糖浓度≥7.0mmol/L 或 HbA1c 浓度≥48mmol/mol(≥6.5%)来确定目前未诊断的糖尿病患者。使用体重指数、高血压、血脂异常史、饮酒习惯、吸烟习惯、体力活动、蔬菜摄入量、情绪压力和抑郁情绪来检查效应修饰。

结果

在年龄调整模型中,独居的男性(n=1098)患未诊断糖尿病的比值比显著升高(比值比 1.45,95%可信区间 1.07,1.96;P=0.018)。在调整生活方式因素后,这种关联略有减弱(比值比 1.40,95%可信区间 1.02,1.91;P=0.036)。在进一步调整上述所有因素后,独居与未诊断糖尿病的存在仍呈边缘显著相关(比值比 1.38,95%可信区间 1.003,1.90;P=0.048)。独居与未检出糖尿病之间的显著关联尤其见于超重、目前吸烟和不活跃的男性,或有上述三个因素中的任何一个的男性。

结论

未诊断糖尿病与独居之间的关联可以部分受可改变的生活方式因素影响。独居的男性,尤其是那些不采取有利生活方式习惯的男性,更有可能患有未诊断的糖尿病。这些人更有可能患有未被发现的糖尿病高血糖症,需要进行血糖测试来确定疾病。

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