Center of Micro and Nanochemistry and Engineering, Department of Chemistry and Biology, Organische Chemie I, Universität Siegen, Adolf-Reichwein-Str. 2, D-57068 Siegen, Germany.
Chem Soc Rev. 2013 Aug 21;42(16):6860-909. doi: 10.1039/c3cs60098j.
Over years, mathematicians, biologists and chemists have capitalised on the highly useful concept of orthogonality for developing sophisticated complex systems. The use of orthogonal pairs ensures that any modification made on one pair does not propagate any effect onto the other. While the concept equally pertains to dynamic supramolecular interactions, interference-free self-assembly built on multiple orthogonal interactions is still limited and the underlying notions are not yet firmly established. Herein, we identify, classify and evaluate dynamic interactions in various orthogonal settings in order to distill out general recommendations for reliable dynamic orthogonality. Our classification has to exclude templating, allosteric and/or cooperative effects as the latter are specific for individual cases only.
多年来，数学家、生物学家和化学家利用正交性这一非常有用的概念来开发复杂的系统。正交对的使用确保了对一对的任何修改都不会传播到另一对。虽然这一概念同样适用于动态超分子相互作用，但基于多个正交相互作用的无干扰自组装仍然有限，并且基本概念尚未牢固确立。在此，我们在各种正交环境中识别、分类和评估动态相互作用，以得出可靠的动态正交性的一般建议。我们的分类必须排除模板、变构和/或协同作用，因为后者仅适用于个别情况。
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