Unger P D, Cohen J M, Thung S N, Gordon R, Pertsemlidis D, Dikman S H
Department of Pathology, Mt Sinai Hospital, New York, NY 10029.
Arch Pathol Lab Med. 1990 Aug;114(8):892-4.
A recurrent adrenal pheochromocytoma is reported in an 18-year-old woman with a family history of multiple endocrine neoplasia type IIA. The tumor was noteworthy for the presence of numerous fine intracytoplasmic lipid droplets confirmed by fat stain. Immunohistochemical studies revealed cytoplasmic positivity for chromogranin and neuron-specific enolase typical of pheochromocytoma. Electron microscopy demonstrated dense-core neurosecretory granules, in addition to the cytoplasmic lipid vacuoles. The presence of lipid within an adrenal pheochromocytoma is rare and, to our knowledge, has been documented in only one previous case report in the literature.
本文报道了一名18岁女性复发性肾上腺嗜铬细胞瘤，该患者有IIA型多发性内分泌腺瘤病家族史。经脂肪染色证实，肿瘤内存在大量细小的胞质内脂质滴，这一点值得关注。免疫组织化学研究显示，嗜铬粒蛋白和神经元特异性烯醇化酶呈细胞质阳性，这是嗜铬细胞瘤的典型表现。电子显微镜检查除发现细胞质脂质空泡外，还可见致密核心神经分泌颗粒。肾上腺嗜铬细胞瘤内出现脂质的情况较为罕见，据我们所知，此前文献中仅有一例相关病例报告。
