Liu Jingbo, Zhao Jian, Li Chen, Yu Ning, Zhang Dongmei, Pan Yaping
Department of Periodontics, School of Stomatology, China Medical Universty, Shenyang, Liaoning, PR China.
Quintessence Int. 2013;44(8):575-83. doi: 10.3290/j.qi.a29752.
To evaluate the changes in the clinical parameters, and the prevalence and quantities of three major periodontopathic bacteria, namely Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia, in subgingival plaque collected from patients with generalized chronic periodontitis (GCP) or generalized aggressive periodontitis (GAgP) in response to nonsurgical periodontal therapy.
73 GCP patients and 57 GAgP patients were enrolled in this study. Clinical parameters, including probing depth (PD), clinical attachment loss (CAL), and Sulcus Bleeding Index (SBI) were measured. The prevalence and quantities of the three bacteria collected from the subgingival plaque were detected by real-time PCR. Both clinical and microbiologic parameters were evaluated at baseline, 4, and 12 weeks after the nonsurgical periodontal treatment.
PD, CAL, and SBI were significantly improved in GCP and GAgP groups at 4 and 12 weeks after nonsurgical periodontal therapy, compared to the baseline levels. The prevalence and quantities of P gingivalis in GCP at baseline (82.19% and 3.35E+5) were statistically higher than those found in GAgP (66.67% and 1.08E+5; P < .05). After therapy, the prevalence and quantities of the three bacteria were sufficiently reduced in both groups at 4 and 12 weeks. There was no significant difference in improvement of clinical and microbiologic parameters between the GCP and GAgP patients after treatment.
There was a difference in P gingivalis prevalence and quantity between the GCP and GAgP patients at baseline. In addition, nonsurgical periodontal therapy was effective in the treatment of clinical symptoms and the major periodontopathic bacterial control between GCP and GAgP patients.
评估从患有广泛性慢性牙周炎（GCP）或广泛性侵袭性牙周炎（GAgP）的患者龈下菌斑中收集的样本，在接受非手术牙周治疗后，临床参数的变化以及三种主要牙周病原菌，即牙龈卟啉单胞菌、伴放线聚集杆菌和福赛坦纳菌的患病率及数量。
本研究纳入了73例GCP患者和57例GAgP患者。测量了临床参数，包括探诊深度（PD）、临床附着丧失（CAL）和龈沟出血指数（SBI）。通过实时聚合酶链反应检测从龈下菌斑中收集的三种细菌的患病率及数量。在非手术牙周治疗后的基线、4周和12周时评估临床和微生物学参数。
与基线水平相比，GCP组和GAgP组在非手术牙周治疗后4周和12周时，PD、CAL和SBI均有显著改善。GCP组基线时牙龈卟啉单胞菌的患病率和数量（82.19%和3.35E+5）在统计学上高于GAgP组（66.67%和1.08E+5；P < .05）。治疗后，两组在4周和12周时三种细菌的患病率和数量均充分降低。治疗后，GCP患者和GAgP患者在临床和微生物学参数改善方面无显著差异。
GCP患者和GAgP患者在基线时牙龈卟啉单胞菌的患病率和数量存在差异。此外，非手术牙周治疗在治疗GCP患者和GAgP患者的临床症状以及控制主要牙周病原菌方面是有效的。
