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[痴呆症预防:潜在治疗方法及如何针对高危患者]

[Dementia prevention: potential treatments and how to target high risk patients].

作者信息

Samaras Nikolaos, Samaras Dimitrios, Frangos Emilia, Forster Alexandre

机构信息

Département de médecine interne, réhabilitation et gériatrie, HUG, 1211 Genève 14.

出版信息

Rev Med Suisse. 2013 May 22;9(387):1116-9.

Abstract

The burden related to the ever-increasing dementia prevalence in older individuals, imposes the implementation of prevention strategies. It is now known that brain lesions related to Alzheimer's disease precede the onset of the first symptoms. Consequently, prevention strategies should be implemented early, before clinically overt dementia. Blood and spine fluid tests, electroencephalogram, brain magnetic resonance and brain nuclear imaging should help physicians to better target "high-risk" patients prone to benefit from such strategies, already in a preclinical disease stage. Since no efficient pharmacological treatments exist for the time being, lifestyle factors such as nutritionand physical exercise are the cornerstones for dementia prevention.

摘要

老年人中痴呆症患病率不断上升所带来的负担,促使预防策略的实施。现在已知与阿尔茨海默病相关的脑部病变先于最初症状的出现。因此,预防策略应在临床显性痴呆出现之前尽早实施。血液和脑脊液检测、脑电图、脑磁共振成像和脑核成像应有助于医生更好地确定那些在临床前疾病阶段就可能从这些策略中获益的“高危”患者。由于目前尚无有效的药物治疗方法,营养和体育锻炼等生活方式因素是预防痴呆症的基石。

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