Yu Li-Li, Li Cui-Ling, Zhang Hui-Ping
Guangxi Maternal and Child Health Care Hospital, Nanning, Guangxi 530000, China.
Zhonghua Nan Ke Xue. 2013 May;19(5):456-9.
The testis is an immune privileged organ where germ cells are protected from autoimmune attack to ensure its reproductive function. Immune tolerance is important for the normal development and function of the testis. Notwithstanding its immune-privileged status, the imbalance between the tolerogenic and the efferent limb of the testicular immune response may lead to autoimmune damage in inflammatory or infected circumstances. Testicular immune regulation is a complex system involving multiple factors and the study of the regulation mechanisms of the testis is of great significance for access to new therapeutic targets. Currently, testicular immunoregulation is thought to be related with blood-testis barrier, Sertoli cells, immune cells, cytokines and androgen.
睾丸是一个免疫特惠器官，生殖细胞在其中受到保护，免受自身免疫攻击，以确保其生殖功能。免疫耐受对于睾丸的正常发育和功能至关重要。尽管睾丸具有免疫特惠状态，但在炎症或感染情况下，睾丸免疫反应的致耐受性和传出支之间的失衡可能导致自身免疫损伤。睾丸免疫调节是一个涉及多种因素的复杂系统，对睾丸调节机制的研究对于找到新的治疗靶点具有重要意义。目前，睾丸免疫调节被认为与血睾屏障、支持细胞、免疫细胞、细胞因子和雄激素有关。
