Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
J Invest Dermatol. 2013 Jul;133(7):1711-3. doi: 10.1038/jid.2013.93.
UVR is one of the major risk factors for melanoma development. However, the mechanisms by which UVR leads to the development of melanoma are not fully understood. Handoko et al. (this issue) explicitly indicate that macrophages are essential for UVR-induced melanocyte proliferation and migration using a neonatal mouse model. Although the functions and mechanisms of macrophages on melanoma development must be investigated further, the link between macrophages and melanocyte responses is striking, suggesting that macrophages might be a target for preventing UVR-induced melanoma.
紫外线辐射（UVR）是黑色素瘤发展的主要危险因素之一。然而，UVR 导致黑色素瘤发展的机制尚不完全清楚。Handoko 等人（本期）使用新生小鼠模型明确表明，巨噬细胞对于 UVR 诱导的黑色素细胞增殖和迁移是必不可少的。尽管巨噬细胞在黑色素瘤发展中的功能和机制仍需进一步研究，但巨噬细胞与黑色素细胞反应之间的联系引人注目，这表明巨噬细胞可能是预防 UVR 诱导的黑色素瘤的一个靶点。
