Shibasaki Atsushi, Kurosawa Hajime, Tamura Gen
Shibasaki Clinic, Japan.
Arerugi. 2013 May;62(5):566-73.
MostGraph is an apparatus for measuring respiratory resistance and respiratory reactance, using the forced oscillation technique. Because these parameters are measured during tidal breathing of subjects, measuring technique is easy with little burden on subjects. In the present study, we conducted spirometry and MostGraph at the same time and examined the clinical significance of parameters of MostGraph.
Subjects were 52 out-patients who underwent a reversibility test. Spirometry and MostGraph are simultaneously practiced both before and after short acting β2 agonist (SABA) inhalation.
Between each parameter of both methods before SABA inhalation, we confirmed significant correlations between many indexes of both manners. Above all, the strongest correlation was found between Fres and FEV1. In relationships between the percent changes of each parameter of both techniques by SABA inhalation, we also found a significant correlation between percent change of Fres and that of FEV1. In addition, there was a hyperbolic relation between change in Fres and that in FEV1 by SABA inhalation.
We confirmed not only that airway narrowing itself significantly correlates with Fres, but also that elastic resistance of respiratory system changes in association with change of airway narrowing. Thus, our findings suggest that the percent change of Fres may provide a diagnostic criterion for a reversibility test in all parameters of MostGraph.
MostGraph是一种采用强迫振荡技术测量呼吸阻力和呼吸电抗的仪器。由于这些参数是在受试者潮式呼吸期间测量的，测量技术简便，对受试者负担小。在本研究中，我们同时进行了肺量计检查和MostGraph测量，并研究了MostGraph参数的临床意义。
研究对象为52例接受可逆性试验的门诊患者。在吸入短效β2激动剂（SABA）前后，同时进行肺量计检查和MostGraph测量。
在吸入SABA前，两种方法的各参数之间，我们证实了两种测量方式的许多指标之间存在显著相关性。其中，Fres与FEV1之间的相关性最强。在吸入SABA后两种技术各参数变化百分比之间的关系中，我们还发现Fres变化百分比与FEV1变化百分比之间存在显著相关性。此外，吸入SABA后Fres变化与FEV1变化之间存在双曲线关系。
我们不仅证实气道狭窄本身与Fres显著相关，而且呼吸系统的弹性阻力随气道狭窄的变化而改变。因此，我们的研究结果表明，Fres的变化百分比可能为MostGraph所有参数的可逆性试验提供诊断标准。
