Seiler T G, Schmidinger G, Fischinger I, Koller T, Seiler T
Institut für Refraktive und Ophthalmo-Chirurgie, Stockerstr. 37, 8002, Zürich, Schweiz.
Ophthalmologe. 2013 Jul;110(7):639-44. doi: 10.1007/s00347-012-2682-0.
More than 10 years after the clinical introduction of corneal cross-linking (CXL) the indications and contraindications are still not yet defined. Fundamental for such a list is the incidence of complications.
A PubMed search for complications of corneal crosslinking published up to March 2013 was carried out.
The published complication rates ranged from 1 % to 10 % depending on the stage of keratoconus. Early postoperative complications were transient stromal haze, sterile infiltrates, endothelium decompensation, delayed epithelial healing and infectious keratitis. Stromal opacity can be a delayed postoperative event.
Complications after corneal cross-linking treatment for keratoconus are rare but the management of these complications may need keratoplasty.
角膜交联术（CXL）临床应用10多年后，其适应证和禁忌证仍未明确。制定这样一份清单的基础是并发症的发生率。
对截至2013年3月发表的关于角膜交联并发症的文献进行PubMed检索。
根据圆锥角膜的阶段不同，已发表的并发症发生率在1%至10%之间。术后早期并发症包括短暂性基质 haze、无菌性浸润、内皮失代偿、上皮愈合延迟和感染性角膜炎。基质混浊可能是术后延迟出现的情况。
圆锥角膜角膜交联治疗后的并发症很少见，但这些并发症的处理可能需要角膜移植术。
