缝隙连接与骨细胞的生物物理调节
Gap Junctions and Biophysical Regulation of Bone Cells.
作者信息
Lloyd Shane A J, Donahue Henry J
机构信息
Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
出版信息
Clin Rev Bone Miner Metab. 2010 Dec 1;8(4):189-200. doi: 10.1007/s12018-011-9084-8.
Abstract
Communication between osteoblasts, osteoclasts, and osteocytes is integral to their ability to build and maintain the skeletal system and respond to physical signals. Various physiological mechanisms, including nerve communication, hormones, and cytokines, play an important role in this process. More recently, the important role of direct, cell-cell communication via gap junctions has been established. In this review, we demonstrate the integral role of gap junctional intercellular communication (GJIC) in skeletal physiology and bone cell mechanosensing.
摘要
成骨细胞、破骨细胞和骨细胞之间的通讯对于它们构建和维持骨骼系统以及响应物理信号的能力而言不可或缺。包括神经通讯、激素和细胞因子在内的各种生理机制在这一过程中发挥着重要作用。最近，通过缝隙连接进行的直接细胞间通讯的重要作用已得到证实。在本综述中，我们阐述了缝隙连接细胞间通讯（GJIC）在骨骼生理学和骨细胞机械传感中的不可或缺的作用。
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