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内分泌干扰化学品:POPs 对女性生殖的一些作用。

Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction.

机构信息

Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland.

出版信息

Int J Endocrinol. 2013;2013:828532. doi: 10.1155/2013/828532. Epub 2013 May 23.

Abstract

Persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polybrominated ethers (PBDEs), chloronaftalens (PCNs), and bisphenol A (BPA), are stable, lipophilic pollutants that affect fertility and cause serious reproductive problems, including ovotoxic action, lack of ovulation, premature ovarian failure (POF), or polycystic ovarian syndrome (PCOS). Most of the representatives of POPs influence the activation of transcription factors, not only activation of aromatic hydrocarbon receptor (AhR), but also the steroid hormone receptors. This minireview will focus on a variety of PAH activities in oocyte, ovary, placenta, and mammary gland. The complexity and diversity of factors belonging to POPs and disorders of the reproductive function of women indicate that the impact of environmental pollution as an important determinant factor in fertility should not be minimize.

摘要

持久性有机污染物(POPs),如多氯二苯并对二恶英(PCDDs)和二苯并呋喃(PCDFs)、多氯联苯(PCBs)和多溴二苯醚(PBDEs)、氯代萘(PCNs)和双酚 A(BPA),是稳定的、亲脂性污染物,会影响生育能力并导致严重的生殖问题,包括卵毒性作用、无排卵、卵巢早衰(POF)或多囊卵巢综合征(PCOS)。大多数 POPs 代表物会影响转录因子的激活,不仅会激活芳香烃受体(AhR),还会激活甾体激素受体。这篇小综述将重点介绍各种 PAH 在卵母细胞、卵巢、胎盘和乳腺中的活性。属于 POPs 的各种因素的复杂性和多样性以及女性生殖功能障碍表明,环境污染作为生育能力的一个重要决定因素的影响不应被低估。

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