Lee E H, Huang J L, Sung Y J, Chai C Y
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
Chin J Physiol. 1990;33(1):49-61.
The paramedian reticular nucleus (PRN) is a triangle midline structure located in the caudal medulla. Electrophysiological and biochemical evidence has suggested that PRN is an important depressor area, and it regulates various cardiovascular functions. The present results have demonstrated that PRN also plays an inhibitory role in a variety of behavioral functions. Lesions of this nucleus produced augmentations of many behavioral measures including: locomotor activity, clockwise and anti-clockwise turnings, as well as stereotyped behavior in rats. It also produced an increased and a more randomized pattern of locomotion. Destructions of the area of nucleus of solitary tract, which affects bradycardia and sometimes hypotension; as well as the midbrain reticular formation, which does not show any cardiovascular responses, yielded much less significant effects. These results confirm previous physiological findings from our laboratory and further suggest that PRN is a unique and independent area which exerts multiple inhibitory actions upon various physiological and behavioral functions in animals.
旁正中网状核（PRN）是位于延髓尾部的一个三角形中线结构。电生理和生化证据表明，PRN是一个重要的降压区域，它调节各种心血管功能。目前的结果表明，PRN在多种行为功能中也发挥着抑制作用。该核团的损伤导致许多行为指标增加，包括：运动活动、顺时针和逆时针旋转，以及大鼠的刻板行为。它还导致运动增加和更随机的运动模式。破坏影响心动过缓且有时影响低血压的孤束核区域；以及不显示任何心血管反应的中脑网状结构，产生的影响则小得多。这些结果证实了我们实验室以前的生理学发现，并进一步表明PRN是一个独特且独立的区域，对动物的各种生理和行为功能发挥多种抑制作用。
