Chiu W T, Lin L S, Lin M T
Department of Surgery, Taipei Medical College, Taiwan, ROC.
Neurosci Res. 1993 May;16(4):311-4. doi: 10.1016/0168-0102(93)90042-o.
Systemic administration of amphetamine (1.25 mg/kg) produced increases of locomotion (including horizontal motion, vertical motion, and total distance travelled), elevations of turnings (including both clockwise and anticlockwise) and inhibition of postural freezing in freely moving rats. All the afore-mentioned activity measures induced by amphetamine were suppressed following electrolytic lesions of the paramedian reticular nucleus (PRN) in rat medulla. In addition, the spontaneous level of either the locomotor activity, the direction of turnings, or the postural freezing were slightly but significantly affected by the PRN lesions. In vivo voltammetric data revealed that amphetamine administration greatly enhanced the striatal dopamine release. Furthermore, the enhanced dopamine release in corpus striatum produced by amphetamine were greatly attenuated by PRN lesions. The results indicate that there exists a PRN-striatal dopamine link in rat brain which mediates the amphetamine-induced increases of locomotion and turnings, as well as decreases of postural freezing.
对自由活动的大鼠进行苯丙胺（1.25毫克/千克）全身给药，会使其运动增加（包括水平运动、垂直运动和总移动距离），旋转次数增加（包括顺时针和逆时针），并抑制姿势性僵住。大鼠延髓旁正中网状核（PRN）经电解损伤后，苯丙胺诱导的上述所有活动指标均受到抑制。此外，PRN损伤对自发运动活动水平、旋转方向或姿势性僵住有轻微但显著的影响。体内伏安数据显示，给予苯丙胺会极大地增强纹状体多巴胺释放。此外，PRN损伤极大地减弱了苯丙胺引起的纹状体多巴胺释放增强。结果表明，大鼠脑中存在PRN-纹状体多巴胺联系，该联系介导了苯丙胺诱导的运动增加、旋转次数增加以及姿势性僵住减少。
