Davies R J, Stradling J R
Sleep Clinic, Churchill Hospital, Headington, Oxford, UK.
Eur Respir J. 1990 May;3(5):509-14.
We have studied the predictive importance of neck circumference, obesity, and several radiographic pharyngeal dimensions for obstructive sleep apnoea (OSA), in 66 patients. OSA was quantified as the mean hourly number of greater than 4% dips in arterial oxygen saturation during sleep. Neck circumference (correlation coefficient (r) = 0.63, 95% confidence interval (C.I.) 0.46-0.76), obesity index (r = 0.54, 95% C.I. 0.39-0.69), hyoid position (r = 0.40, 95% C.I. 0.17-0.59), soft palate length (r = 0.31, 95% C.I. 0.08-0.51), and hard palate-to-spine angle (r = 0.29, 95% C.I. 0.04-0.49), correlated significantly with saturation dips in single regression analysis. In stepwise multiple linear regression analysis (saturation dip rate as the dependent variable), only neck size and retroglossal space were significant independent correlates (total r2 = 0.42, 95% C.I. 0.22-0.61, p less than 0.0001). We conclude that the relationships between general obesity, hyoid position, soft palate length, and OSA are probably secondary to variation in neck circumference.
我们对66例患者进行了研究，探讨颈围、肥胖及几个咽部影像学测量指标对阻塞性睡眠呼吸暂停（OSA）的预测价值。OSA的量化指标为睡眠期间动脉血氧饱和度每小时下降幅度大于4%的平均次数。在单因素回归分析中，颈围（相关系数（r）=0.63，95%置信区间（C.I.）0.46 - 0.76）、肥胖指数（r = 0.54，95% C.I. 0.39 - 0.69）、舌骨位置（r = 0.40，95% C.I. 0.17 - 0.59）、软腭长度（r = 0.31，95% C.I. 0.08 - 0.51）以及硬腭与脊柱夹角（r = 0.29，95% C.I. 0.04 - 0.49）均与血氧饱和度下降显著相关。在逐步多元线性回归分析中（以血氧饱和度下降率作为因变量），只有颈围和舌后间隙是显著的独立相关因素（总r2 = 0.42，95% C.I. 0.22 - 0.61，p < 0.0001）。我们得出结论，一般肥胖、舌骨位置、软腭长度与OSA之间的关系可能继发于颈围的变化。
