Vernon Philip J, Zeh Iii Herbert J, Lotze Michael T
Department of Surgery; Hillman Cancer Center; University of Pittsburgh Cancer Institute; Pittsburgh, PA USA.
Oncoimmunology. 2013 May 1;2(5):e24184. doi: 10.4161/onci.24184.
We identified a critical role for receptor for advanced glycation end products (RAGE) in the intratumoral accumulation of myeloid-derived suppressor cells (MDSCs) during pancreatic carcinogenesis. The absence of RAGE markedly delayed neoplasia and limited MDSC accumulation in mice expressing an oncogenic variant of . In spite of MDSCs, these mice accumulated non-immunosuppressive macrophages. Thus, RAGE regulates carcinogenesis and consequent myeloid responses.
我们发现晚期糖基化终末产物受体（RAGE）在胰腺癌发生过程中髓源性抑制细胞（MDSC）的瘤内积聚中起关键作用。RAGE缺失显著延迟了肿瘤形成，并限制了表达致癌变体的小鼠体内MDSC的积聚。尽管存在MDSC，但这些小鼠积聚的是非免疫抑制性巨噬细胞。因此，RAGE调节肿瘤发生及随之而来的髓系反应。
